Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization
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چکیده
منابع مشابه
Propranolol inhibits hyphal development in Candida albicans.
Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.
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1 Aberdeen Fungal Group, MRC Centre for Medical Mycology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom, 2 Mucosal & Salivary Biology Division, Dental Institute, King’s College London, United Kingdom, 3 Department of Microbial Pathogenicity Mechanisms, Hans Knoell Institute, and Friedrich Schiller University, ...
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ژورنال
عنوان ژورنال: mBio
سال: 2018
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.01226-18